Associations between , and and lipid-lowering efficacy and pharmacokinetics of fluvastatin: a meta-analysis.

This meta-analysis was designed to investigate the associations between ,  and  and the lipid-lowering effects and pharmacokinetics of fluvastatin. Studies were searched from inception to March 2023, including three SNPs related to fluvastatin, , and . Weighted mean differences and corresponding 95% CIs were analyzed to evaluate the associations between SNPs and outcomes. 521T>C was associated with lower total cholesterol and low-density lipoprotein reduction. Patients carrying 521CC or total cholesterol had a significantly higher area under the curve than those carrying 521TT, but no significant difference existed. and may be associated with the efficacy and pharmacokinetics of fluvastatin.