There has been growing research interest in developing methodology to evaluate healthcare centers' performance with respect to patient outcomes. Conventional assessments can be conducted using fixed or random effects models, as seen in provider profiling. We propose a new method, using fusion penalty to cluster healthcare centers with respect to a survival outcome. Without any prior knowledge of the grouping information, the new method provides a desirable data-driven approach for automatically clustering healthcare centers into distinct groups based on their performance. An efficient alternating direction method of multipliers algorithm is developed to implement the proposed method. The validity of our approach is demonstrated through simulation studies, and its practical application is illustrated by analyzing data from the national kidney transplant registry.
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http://dx.doi.org/10.1002/sim.9825 | DOI Listing |
The LOV2 domain is commonly harnessed as a source of light-based regulation in engineered optogenetic switches. In prior work, we used LOV2 to create a light-regulated Dihydrofolate Reductase (DHFR) enzyme and showed that structurally disperse mutations in DHFR were able to tune the allosteric response to light. However, it remained unclear how light allosterically activates DHFR, and how disperse mutations modulate the allosteric effect.
View Article and Find Full Text PDFCopy number variants (CNVs) are DNA gains or losses involving >50 base pairs. Assessing CNV effects on disease risk requires consideration of several factors. First, there are no natural definitions for CNV loci.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
February 2025
Department of Optoelectronic Engineering, Jinan University, Guangzhou, Guangdong 510632, China. Electronic address:
There are many types of fish maw with significantly varying prices. The specific type directly affects its market value and medicinal efficacy. This paper proposes a fish maw type recognition method based on Wasserstein generative adversarial network combined with gradient penalty (WGAN-GP) and spectral fusion.
View Article and Find Full Text PDFPlant J
November 2024
College of Electronic Information and Physics, Central South University of Forestry and Technology, Changsha, 41004, Hunan, China.
Sensors (Basel)
September 2024
Department of Civil Engineering and Engineering Mechanics, Columbia University, New York, NY 10027, USA.
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