AI Article Synopsis
- The review aimed to assess the connection between osteoarthritis (OA) and cardiovascular diseases (CVD), focusing on their risk factors, underlying mechanisms, and the role of chronic pain in this relationship.
- It emphasized the importance of conducting more clinical and observational studies on the efficacy and safety of chondroitin sulfate (CS), particularly its parenteral form (Chondroguard), for patients suffering from chronic pain due to OA and CVD.
- Additionally, the review called for improved clinical guidelines for treating chronic pain in OA patients at risk for CVD, highlighting the need for strategies that enhance mobility and integrate disease-modifying osteoarthritis drugs (DMOADs) into treatment plans.
Article Abstract
The purpose of the review of scientific medical literature was to evaluate the data of the epidemiology of osteoarthritis (OA) and cardiovascular diseases (CVD) with the analysis of risk factors, pathophysiological and pathobiochemical mechanisms of the relationship between OA and the risk of developing CVD in the presence of chronic pain, modern strategies for screening and management of this cohort of patients, the mechanism of action and pharmacological effects of chondroitin sulfate (CS). Conclusions were drawn about the need for additional clinical and observational studies of the efficacy and safety of the parenteral form of CS (Chondroguard) in patients with chronic pain in OA and CVD, improvement of clinical recommendations for the treatment of chronic pain in patients with OA and cardiovascular risk, with special attention to interventions that eliminate mobility restrictions in patients and the inclusion of basic and adjuvant therapy with DMOADs to achieve the goals of multipurpose monotherapy in patients with contraindications to standard therapy drugs.
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| http://dx.doi.org/10.17116/jnevro202312305120 | DOI Listing |
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