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Somitic positional information guides self-organized patterning of snake scales. | LitMetric

Somitic positional information guides self-organized patterning of snake scales.

Sci Adv

Laboratory of Artificial & Natural Evolution (LANE), Department of Genetics & Evolution, University of Geneva, CH-1211 Geneva, Switzerland.

Published: June 2023

AI Article Synopsis

Article Abstract

Two influential concepts in tissue patterning are Wolpert's positional information and Turing's self-organized reaction-diffusion (RD). The latter establishes the patterning of hair and feathers. Here, our morphological, genetic, and functional-by CRISPR-Cas9-mediated gene disruption-characterization of wild-type versus "scaleless" snakes reveals that the near-perfect hexagonal pattern of snake scales is established through interactions between RD in the skin and somitic positional information. First, we show that ventral scale development is guided by hypaxial somites and, second, that ventral scales and epaxial somites guide the sequential RD patterning of the dorsolateral scales. The RD intrinsic length scale evolved to match somite periodicity, ensuring the alignment of ribs and scales, both of which play a critical role in snake locomotion.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266723PMC
http://dx.doi.org/10.1126/sciadv.adf8834DOI Listing

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