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Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications. | LitMetric

AI Article Synopsis

  • Amino acid crystals, particularly glycine, are promising for piezoelectric applications in medical implants due to their high efficiency and safety, but issues like brittleness and poor water resistance limit their use.
  • This study introduces a method to create flexible, biodegradable nanofibers of glycine crystals within polycaprolactone (PCL), resulting in a material that maintains strong piezoelectric properties and exhibits impressive ultrasound output.
  • The new glycine-PCL nanofibers are used to design a biodegradable ultrasound transducer that significantly improves survival rates in mice with brain tumors, showcasing potential for both cancer treatment and broader medical applications.

Article Abstract

Amino acid crystals are an attractive piezoelectric material as they have an ultrahigh piezoelectric coefficient and have an appealing safety profile for medical implant applications. Unfortunately, solvent-cast films made from glycine crystals are brittle, quickly dissolve in body fluid, and lack crystal orientation control, reducing the overall piezoelectric effect. Here, we present a material processing strategy to create biodegradable, flexible, and piezoelectric nanofibers of glycine crystals embedded inside polycaprolactone (PCL). The glycine-PCL nanofiber film exhibits stable piezoelectric performance with a high ultrasound output of 334 kPa [under 0.15 voltage root-mean-square (Vrms)], which outperforms the state-of-the-art biodegradable transducers. We use this material to fabricate a biodegradable ultrasound transducer for facilitating the delivery of chemotherapeutic drug to the brain. The device remarkably enhances the animal survival time (twofold) in mice-bearing orthotopic glioblastoma models. The piezoelectric glycine-PCL presented here could offer an excellent platform not only for glioblastoma therapy but also for developing medical implantation fields.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266740PMC
http://dx.doi.org/10.1126/sciadv.adg6075DOI Listing

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