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| http://dx.doi.org/10.1073/pnas.2221911120 | DOI Listing |
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Bayesian semiparametric inference in longitudinal metabolomics data.
Sci Rep
December 2024
Department of Statistical Science, Duke University, Durham, 27708-0251, USA.
The article is motivated by an application to the EarlyBird cohort study aiming to explore how anthropometrics and clinical and metabolic processes are associated with obesity and glucose control during childhood. There is interest in inferring the relationship between dynamically changing and high-dimensional metabolites and a longitudinal response. Important aspects of the analysis include the selection of the important set of metabolites and the accommodation of missing data in both response and covariate values.
View Article and Find Full Text PDFComparative efficacy and safety of treatment regimens for Pneumocystis jirovecii pneumonia in people living with HIV - A systematic review and network meta-analysis of randomized controlled trials.
Clin Microbiol Infect
December 2024
BioTechMed-Graz, Graz, Austria; Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Graz, Austria. Electronic address:
Background: Pneumocystis jirovecii pneumonia (PCP) is a serious opportunistic infection in people living with HIV (PWH) who have low CD4 counts. Despite its side effects, trimethoprim-sulfamethoxazole (TMP-SMX) is currently considered the primary treatment for PCP.
Objectives: To compare the efficacy (treatment-failure and mortality) and tolerability (treatment change) of PCP treatment-regimens with a frequentist network meta-analysis (NMA).
Rapid and precise treatment selection for antimicrobial-resistant infection enabled by a nano-dilution SlipChip.
Biosens Bioelectron
December 2024
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China; Zhengzhou Industrial Technology Research Institute of Shanghai Jiao Tong University, Zhengzhou, 450016, China. Electronic address:
Antimicrobial resistance (AMR) has become an increasingly severe threat to global health, and AMR-associated infection is one of the leading causes of death around the world. Due to the long turnaround time and the limited flexibility and availability of current antimicrobial susceptibility testing (AST) methods, a large portion of patients with bacterial infections are still treated empirically, increasing the risk of mistreatment. To address the demand for precision treatment of bacterial infections, we developed a nano-dilution SlipChip (nd-SlipChip)-based systematic evaluation method, which facilitates rapid, logic feedback for the assessment of antibiotics, antibiotic combinations, and phage therapy.
View Article and Find Full Text PDFDevelopment of a Nano-toughened multifunctional composite hydrogel based on chitosan and its applications in catalytic and flexible sensors.
Int J Biol Macromol
December 2024
School of Chemical Engineering, Changchun University of Technology, Changchun 130012, China.
In this study, we developed a novel composite catalytic hydrogel, which integrates excellent mechanical properties, catalytic activity, and sensing performance. Discarded hydrogel sensors are reused as templates for in-situ generation of metal nanoparticles, and multifunctional hydrogels combining sensing and catalysis are realized. Polyacrylamide (PAM) provides a three-dimensional network structure, while octadecyl methacrylate (SMA) acts as a hydrophobic association center, enhancing the structural stability of the hydrogel.
View Article and Find Full Text PDFPleozymes: Pleiotropic Oxidized Carbon Nanozymes Enhance Cellular Metabolic Flexibility.
Nanomaterials (Basel)
December 2024
Center for Genomics and Precision Medicine, Institute of Bioscience and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA.
Our group has synthesized a pleiotropic synthetic nanozyme redox mediator we term a "pleozyme" that displays multiple enzymatic characteristics, including acting as a superoxide dismutase mimetic, oxidizing NADH to NAD, and oxidizing HS to polysulfides and thiosulfate. Benefits have been seen in acute and chronic neurological disease models. The molecule is sourced from coconut-derived activated charcoal that has undergone harsh oxidization with fuming nitric acid, which alters the structure and chemical characteristics, yielding 3-8 nm discs with broad redox potential.
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