NIR-II Responsive Nanohybrids Incorporating Thermosensitive Hydrogel as Sprayable Dressing for Multidrug-Resistant-Bacteria Infected Wound Management.

Developing an effective dressing against bacterial infection and synchronously addressing wound complications, such as bleeding, long-term inflammation, and reinfection, are highly desirable in clinical practice. In this work, a second near-infrared (NIR-II) responsive nanohybrid consisting of mipenem encapsulated iposome with old-shell and lipopolysaccharide (LPS)-targeting ptamer, namely , is constructed for bacteria elimination. Benefiting from the delicate structure, exhibits strong affinity and a reliable photothermal/antibiotic therapeutic effect toward multidrug-resistant (). Furthermore, by incorporating with a thermosensitive hydrogel poly(lactic--glycolic acid)-polyethylene glycol-poly(lactic--glycolic acid) (PLGA-PEG-PLGA), a sprayable dressing was prepared, which enables a quick on-demand gelation (10 s) for wound hemostasis and offers excellent photothermal/antibiotic efficacy to sterilize the infected wound. Additionally, provides satisfactory wound-healing environments by reeducating wound-associated macrophages for inflammation alleviation and forming a gel layer to block exogenous bacterial reinfection. This biomimetic hydrogel reveals excellent bacteria eradication and wound recovery effectiveness, demonstrating its promising potential for managing complicated infected wounds.