How adult stem cells signal in vivo over time to coordinate their fate and behavior across self-renewing tissues remains a challenging question. In this issue, Moore et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202302095) combine high-resolution live imaging in mice with machine learning tools to reveal temporally regulated tissue-scale patterns of Ca2+ signaling orchestrated by cycling basal stem cells of the skin epidermis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267592 | PMC |
| http://dx.doi.org/10.1083/jcb.202305022 | DOI Listing |
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