AI Article Synopsis
- * Epigenetic drugs (epi-drugs) can potentially improve cancer treatment when used in combination with standard therapies, helping to overcome resistance in cancer cells.
- * The review highlights how these combination therapies could be more effective if the challenges in developing epi-drugs are addressed.
Article Abstract
Epigenetic changes play a significant role in cancer progression, maintenance and therapy resistance. Generally, epigenetic modifications are reversible, thereby gaining attention for therapeutic interventions. However, limited efficacy and therapy resistance remain the significant limitations of conventional and epigenetic anticancer therapies. Recently, combination therapies with epigenetic drugs (epi-drugs) and conventional anticancer treatment have gained widespread attention. Here, epi-drugs are administered with anticancer therapies to increase their therapeutic efficacy and sensitize cancer cells resistant to therapies. This review summarizes the mechanism of epi-drugs in reversing resistance to anticancer therapies. Further, the challenges faced during developing combination therapies with epi-drugs are discussed. We believe the clinical benefit of combination therapies could be increased by overcoming the challenges faced during epi-drug development.
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| http://dx.doi.org/10.2217/epi-2023-0142 | DOI Listing |
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