AI Article Synopsis
- - HempChoice® Hemp Oil Extract is a hemp-derived product mostly containing 55-75% cannabidiol (CBD) along with other cannabinoids and terpenes, with no significant safety concerns shown in multiple studies.
- - Safety studies, including a 90-day trial, revealed that the extract was well tolerated with no serious side effects, and any minor changes observed were considered temporary and reversible.
- - The extract's no observed adverse effect level (NOAEL) was established at 185.90 mg/kg body weight/day based on testing in Sprague-Dawley rats, indicating a safe threshold for consumption.
Article Abstract
HempChoice® Hemp Oil Extract (Geocann, LLC) is an extract of the aerial parts of hemp ( L.) primarily comprised of 55-75% cannabidiol (CBD), 1-15% other phytocannabinoids and 1-15% terpenes. The results of multiple safety studies demonstrated that it was non-mutagenic in an Ames and mammalian cell micronucleus. test and was well tolerated in a 14-day range-finding study at dose levels up to 96.03. mg/kg BW/day. In the 90-day study, no HempChoice® Hemp Oil Extract-related significant changes were noted in weekly BW, daily BW gain, food consumption, functional observational battery or motor activity assessment. In addition, no HempChoice® Hemp Oil Extract related mortalities, abnormal clinical observations and ophthalmological changes were reported. Some HempChoice® Hemp Oil Extract-related changes were reported in the hematology and clinical chemistry parameters evaluated. These changes were not outside the normal range and were considered reversible during the 28-day recovery period. No macroscopic findings were reported, and histopathological changes related to HempChoice® Hemp Oil Extract exposure were limited to adaptive changes in the liver which were not observed in the recovery group animals. The no observed adverse effect level (NOAEL) for HempChoice® Hemp Oil Extract was determined to be 185.90 mg/kg BW/day in male and female Sprague-Dawley rats.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258502 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2023.e16913 | DOI Listing |
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