Short term tissue cultures on space substrate were made from 13 samples of normal colonic mucosa and non-tumours colonic lesions as well as from 28 samples of epithelial colonic tumours. The growth and morphological features of cultivated tumours were mostly connected with their original histological structure and biological behaviour. Epithelial structures from adenoma and carcinoma survived longer than those from non-tumorous lesions. Epithelial cells from villous adenomas and from familiar polypous colonic adenomas showed increased proliferation on space substrate similar to the growth of carcinoma cells.
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