AI Article Synopsis
- - Technetium-labeled radiotracers like Tc-99m PYP are used to diagnose transthyretin cardiac amyloidosis (ATTR-CA), but the significance of its uptake outside the heart (extracardiac uptake) is not well understood.
- - In the SCAN-MP study, primarily involving Black and Hispanic participants over 60 with heart failure, researchers found that 11.1% of subjects had extracardiac Tc-99m PYP uptake, with kidney and bone uptake being the most common.
- - Despite the discovery of extracardiac uptake in these participants, only 1.1% had findings that were clinically actionable, indicating that most of the uptake was not significant for further
Article Abstract
Introduction: Technetium-labeled bone-avid radiotracers can be used to diagnose transthyretin cardiac amyloidosis (ATTR-CA). Extracardiac uptake of technetium pyrophosphate (Tc-99m PYP) in this context has not been extensively explored and its significance is not well characterized. We assessed extracardiac Tc-99m PYP uptake in individuals undergoing nuclear scintigraphy and the extent of clinically actionable findings.
Methods: The Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Populations (SCAN-MP) study utilizes Tc-99m PYP imaging to identify ATTR-CA in self-identified Black and Caribbean Hispanic participants ≥ 60 years old with heart failure. We characterized the distribution of extracardiac uptake, including stratification of findings by timing of scan (1 hour vs 3 hours after Tc-99m PYP administration) and noted any additional testing in these subjects.
Results: Of 379 participants, 195 (51%) were male, 306 (81%) Black race, and 120 (32%) Hispanic ethnicity; mean age was 73 years. Extracardiac Tc-99m PYP uptake was found in 42 subjects (11.1%): 21 with renal uptake only, 14 with bone uptake only, 4 with both renal and bone uptake, 2 with breast uptake, and 1 with thyroid uptake. Extracardiac uptake was more common in subjects with Tc-99m PYP scans at 1 hour (23.8%) than at 3 hours (6.2%). Overall, four individuals (1.1%) had clinically actionable findings.
Conclusion: Extracardiac Tc-99m PYP uptake manifested in about 1 in 9 SCAN-MP subjects but was clinically actionable in only 1.1% of cases.
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| http://dx.doi.org/10.1007/s12350-023-03310-7 | DOI Listing |
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