AI Article Synopsis
- Preterm birth (PTB) occurs when a baby is born before 37 weeks of gestation and is a leading cause of health issues for newborns.
- A study involving 384 cases of premature births and 644 control subjects in Japan aimed to find genetic factors linked to PTB but found no significant results.
- The researchers hope their findings will serve as a foundation for future studies that include larger groups to better understand the genetics related to preterm birth.
Article Abstract
Preterm birth (PTB), defined as the birth of a baby at <37 weeks of gestation, is known to be the main cause of neonatal morbidity and mortality. Here, we report genetic associations between preterm birth and gestational age in a Japanese population. We conducted a genome-wide association study (GWAS) of 384 cases who delivered prematurely and 644 controls and considered gestational age as a quantitative trait in 1028 Japanese women. Unfortunately, we were unable to identify any significant variants associated with PTB or gestational age using the current sample. We also examined genetic associations previously reported in European populations and identified no associations, even with the genome-wide subthreshold (p value < 10). This data report aims to provide summary statistics of current GWASs on PTB in a Japanese population for future meta-analyses of genetics and PTB with larger sample sizes.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264385 | PMC |
| http://dx.doi.org/10.1038/s41439-023-00246-9 | DOI Listing |
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