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| http://dx.doi.org/10.1038/s41392-023-01513-5 | DOI Listing |
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Chemotherapy on hematological and biochemical parameters in breast cancer patients.
Caspian J Intern Med
October 2024
Department of Microbiology, GITAM Institute of Medical Sciences and Research, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh, India.
Article Synopsis
- The study investigates the effects of AC chemotherapy (Adriamycin and Cytoxan) on antioxidant enzymes and blood-related parameters in breast cancer patients.
- It involved 40 patients, with data collected before and after three cycles of treatment, using spectrophotometric techniques to measure enzyme levels.
- Results indicated a significant decrease in antioxidant enzymes and hematological parameters after treatment, suggesting that AC chemotherapy causes notable alterations in the body's oxidant/antioxidant balance.
Characterization of polyploidy in cancer: Current status and future perspectives.
Int J Biol Macromol
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Department of Biomedical Science and Technology, School of Biological Sciences, Ramakrishna Mission Vivekananda Educational Research Institute (RKMVERI), Kolkata, India. Electronic address:
Various cancers frequently exhibit polyploidy, observed in a condition where a cell possesses more than two sets of chromosomes, which is considered a hallmark of the disease. The state of polyploidy often leads to aneuploidy, where cells possess an abnormal number or structure of chromosomes. Recent studies suggest that oncogenes contribute to aneuploidy.
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Centre de Biologie Structurale (CBS), CNRS, INSERM, Univ Montpellier, Montpellier, France.
NCYM is a cis-antisense gene of MYCN oncogene and encodes an oncogenic protein that stabilizes MYCN via inhibition of GSK3b. High NCYM expression levels are associated with poor clinical outcomes in human neuroblastomas, and NCYM overexpression promotes distant metastasis in animal models of neuroblastoma. Using vacuum-ultraviolet circular dichroism and small-angle X-ray scattering, we previously showed that NCYM has high flexibility with partially folded structures; however, further structural characterization is required for the design of anti-cancer agents targeting NCYM.
View Article and Find Full Text PDFCemiplimab in locally advanced or metastatic cutaneous squamous cell carcinoma: prospective real-world data from the DRUG Access Protocol.
Lancet Reg Health Eur
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Department of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
Background: The DRUG Access Protocol provides patients with cancer access to registered anti-cancer drugs that are awaiting reimbursement in the Netherlands and simultaneously collects prospective real-world data (RWD). Here, we present RWD from PD-1 blocker cemiplimab in patients with locally advanced or metastatic cutaneous squamous cell carcinoma (laCSCC; mCSCC).
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Current Progress and Emerging Role of Essential Oils in Drug Delivery Therapeutics.
Curr Drug Deliv
February 2024
School of Pharmacy, Al-Karim University, Katihar 854106, Bihar, India.
The utilization of novel drug delivery systems loaded with essential oils has gained significant attention as a promising approach for biomedical applications in recent years. Plants possess essential oils that exhibit various medicinal properties, i.e.
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