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Alzheimers Dement
December 2024
University of Kentucky College of Medicine, Sanders-Brown Center on Aging, Lexington, KY, USA.
Background: Our lab recently developed 2 mouse monoclonal antibodies that preferentially react with "distressed astrocytes". One monoclonal, 26A6, was found to react preferentially with a form of the Ca2+/calmodulin-dependent protein phosphatase, calcineurin (CN), that has been cleaved by calpain, to generate a 48 kDa CN fragment (∆CN). We recently published a characterization of this antibody.
View Article and Find Full Text PDFProgress in understanding the infrared spectrum of the H2O-O2 dimer.
J Chem Phys
January 2025
Department of Physics and Astronomy, University of Calgary, 2500 University Drive North West, Calgary, Alberta T2N 1N4, Canada.
Spectra of the weakly bound H2O-O2 dimer are studied in the region of the H2O ν2 band using a tunable quantum cascade laser to probe a pulsed supersonic slit jet expansion. These are the first gas-phase infrared spectra of H2O-O2 and among only a few such results for O2-containing complexes. Almost 100 infrared lines are assigned based on the ground state combination differences from the microwave spectrum of H2O-O2.
View Article and Find Full Text PDFContext familiarity is a third kind of episodic memory distinct from item familiarity and recollection.
iScience
December 2024
Florida Institute of Technology, Department of Psychology, 150 W. University Dr., Melbourne, FL 32905, USA.
Episodic memory is accounted for with two processes: "familiarity" when generally recognizing an item and "recollection" when retrieving the full contextual details bound with the item. We tested a combination of item recognition confidence and source memory, focusing upon three conditions: "item-only hits with source unknown" ('item familiarity'), "low-confidence hits with correct source memory" ('context familiarity'), and "high-confidence hits with correct source memory" ('recollection'). Behaviorally, context familiarity was slower than the others during item recognition, but faster during source memory.
View Article and Find Full Text PDFThe Value of Tracheal Visualization in Tracheostomized Patients in Skilled and Long-Term Care Homes.
Cureus
January 2025
Department of Research and Development, Dr. Ferrer BioPharma, Hallandale Beach, USA.
Objective This study aims to assess the impact of tracheal visualization on weaning success among tracheostomized patients in skilled and long-term care facilities, highlighting its role in reducing complications and enhancing clinical outcomes. Methods A retrospective observational study was conducted on tracheostomized patients residing in skilled nursing homes in Florida between 2018 and 2023. The study included individuals aged 18 years or older with established tracheostomies.
View Article and Find Full Text PDFDFedGFM: Pursuing global consistency for Decentralized Federated Learning via global flatness and global momentum.
Neural Netw
December 2024
The School of Cyber Science and Technology, Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China. Electronic address:
To tackle high communication costs and privacy issues in Centralized Federated Learning (CFL), Decentralized Federated Learning (DFL) is an alternative. However, a significant discrepancy exists between local updates and the expected global update, known as client drift, which arises from inconsistency and heterogeneous data. Previous research in the DFL field has focused on local information during client updates, without considering global information, which fails to alleviate the client drift issue.
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