Objective: The objective of this study was to characterize driving safety and the factors affecting it among physicians in combat units in the Israel Defense Forces (IDF), who have high workloads and substantial sleep deprivation, which could influence driving safety.
Methods: This cross-sectional study included physicians in combat units who had a personal vehicle equipped with an advanced driver assistance system (ADAS). The study outcomes included events such as drowsy driving or falling asleep while driving, as well as motor vehicle accidents (MVAs), obtained from self-reports from digital questionnaires, and objective ADAS driving safety scores. Sleep hours, burnout scores (Maslach Burnout Inventory), combat activity levels, and demographic characteristics were obtained through digital questionnaires, and their effects on the outcomes were analyzed.
Results: Sixty-four military combat unit physicians were included in the study. No differences in drowsy driving, MVAs, or ADAS scores were found between the 2 combat activity level groups. The results showed that 82% of participants reported dozing off while driving, and this was positively correlated with accelerations (β = 0.19; = .004) and negatively correlated (adjusted = 21%) with hours of sleep (β = -0.28; = .001). Eleven percent reported experiencing MVAs, none of whom required hospitalization. The mean ADAS safety score was 87.17 ± 7.54, and this was positively correlated with the cynicism score (β = 1.45; = .04; adjusted = 4.7%). No association between dozing off/falling asleep while driving and the reported MVAs was found ( = .10 and = .27, respectively).
Conclusion: Physicians in combat units have a low incidence of MVAs and high ADAS scores. This may be attributed to the high safety climate enforced in military units. However, the high rate of dozing off while driving highlights the importance of addressing driving safety in this population.
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http://dx.doi.org/10.1080/15389588.2023.2209901 | DOI Listing |
Microbiome
January 2025
Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China.
Background: The widespread selective pressure of antibiotics in the environment has led to the propagation of antibiotic resistance genes (ARGs). However, the mechanisms by which microbes balance population growth with the enrichment of ARGs remain poorly understood. To address this, we employed microcosm cultivation at different antibiotic (i.
View Article and Find Full Text PDFACS Nano
January 2025
Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, 119074, Singapore.
The emerging combination of chemotherapy and radionuclide therapy has been actively investigated to overcome the limitations of monotherapy and augment therapeutic efficacy. However, it remains a challenge to design a single delivery vehicle that can incorporate chemotherapeutics and radionuclides into a compact structure. Here, a chelator DOTA- or NOTA-modified Evans blue conjugated camptothecin molecule (EB-CPT) nanoprodrug was synthesized, which could self-assemble into nanoparticles due to its inherent amphiphilicity.
View Article and Find Full Text PDFJ Sleep Res
January 2025
Flinders Health and Medical Research Institute: Sleep Health, Flinders University, Adelaide, South Australia, Australia.
Sleepiness-related errors are a leading cause of driving accidents, requiring drivers to effectively monitor sleepiness levels. However, there are inter-individual differences in driving performance after sleep loss, with some showing poor driving performance while others show minimal impairment. This research explored if there are differences in self-reported sleepiness and driving performance in healthy drivers who exhibited vulnerability or resistance to objective driving impairment following extended wakefulness.
View Article and Find Full Text PDFAAPS J
January 2025
Clinical Pharmacology Modeling and Simulation, Amgen, One Amgen Center Drive, Thousand Oaks, CA, 91320-0777, USA.
Sotorasib is a novel KRAS inhibitor that has shown robust efficacy, safety, and tolerability in patients with KRAS mutation. The objectives of the population pharmacokinetic (PK) analysis were to characterize sotorasib population PK in healthy subjects and patients with advanced solid tumors with KRAS mutation from 6 clinical studies, evaluate the effects of intrinsic and extrinsic factors on PK parameters, and perform simulations to further assess the impact of identified covariates on sotorasib exposures. A two-compartment disposition model with three transit compartments for absorption and time-dependent clearance and bioavailability well described sotorasib PK.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
December 2024
Sichuan Provincial Engineering Research Center of Formation Principle and Quality Evaluation of Genuine Medicinal Materials, Sichuan Engineering Technology Research Center of Genuine Regional Drug, Translational Chinese Medicine Key Laboratory of Sichuan Province, Key Laboratory of Biological Evaluation of TCM Quality of the State Administration of Traditional Chinese Medicine, Sichuan Institute for Translational Chinese Medicine Chengdu 610041, China.
Traditional Chinese medicine(TCM) resources refer to the total reserves of plants, animals, and minerals that can be used as raw materials of TCM(including Chinese medicial materials, TCM decoction pieces, TCM dispensing granules, traditional Chinese patent medicine, and TCM hospital preparation) and folk herbal medicine, which served as the material basis of inheritance, innovation, and development of TCM. In recent years, the sustainable utilization of TCM resources has received high attention and acquired a series of significant achievements in resource survey, quality evaluation, resource protection, innovative technology, and development and utilization, which effectively promoted the sustainable utilization of TCM resources and high-quality development of the TCM industry. The most urgent issue currently is to shift the focus of the research on the sustainable utilization of TCM resources from a sustainable utilization technology system to a sustainable utilization evaluation indicator system.
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