AI Article Synopsis
- The study discusses three cases of high-grade gliomas with O-Methylguanine-DNA Methyl-transferase (MGMT) methylation, highlighting distant recurrences despite initial successful treatment using the Stupp protocol.* -
- All patients showed stable conditions at the original tumor site when distant recurrences occurred, suggesting effective local control, but ultimately faced poor outcomes after the metastasis.* -
- One case involved Next Generation Sequencing (NGS), which revealed a high tumor mutational burden in the recurrent tumor, emphasizing the need to identify risk factors and correlations for more effective treatment strategies to reduce distant recurrences.*
Article Abstract
We present three cases of O-Methylguanine-DNA Methyl-transferase (MGMT) methylated high grade gliomas with distant recurrence. All three patients had a radiographic stability of original tumor site at time of distant recurrence indicating impressive local control with Stupp protocol in patients with a MGMT methylated tumors. All patients had a poor outcome after distant recurrence. For one patient Next Generation Sequencing (NGS) was available for both original and recurrent tumor and did not reveal any difference other than high tumor mutational burden in the distant recurrent tumor. Understanding risk factors of distant recurrence in MGMT methylated tumors and investigating correlations between recurrences will help plan therapeutic strategies to prevent distant recurrence and improve survival of these patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259672 | PMC |
| http://dx.doi.org/10.26420/annhematoloncol.2023.1421 | DOI Listing |
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