AI Article Synopsis
- Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) share similar metabolic issues, particularly insulin resistance and metabolic alterations.
- Research shows that some glucose-lowering medications help with both conditions, but effectiveness varies, and the reasons why some work better for NAFLD are still debated.
- It's suggested that improving the metabolism of free fatty acids might be crucial for treating NAFLD, indicating that certain medications could target this issue effectively.
Article Abstract
Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) are metabolic disorders connected by common pathophysiological mechanisms. Since insulin resistance (IR) and metabolic alterations are common to both conditions, almost all glucose-lowering agents which improve IR have also been studied in patients with NAFLD. Some have shown great efficacy, others none. Thus, the mechanisms behind the efficacy of these drugs in improving hepatic steatosis, steatohepatitis, and eventually fibrosis remain controversial. Glycaemic control improves T2D, but probably has limited effects on NAFLD, as all glucose-lowering agents ameliorate glucose control but only a few improve NAFLD features. In contrast, drugs that either improve adipose tissue function, reduce lipid ingestion, or increase lipid oxidation are particularly effective in NAFLD. We therefore hypothesise that improved free fatty acid metabolism may be the unifying mechanism behind the efficacy of some glucose-lowering agents on NAFLD and may represent the key to NAFLD treatment.
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| http://dx.doi.org/10.1002/dmrr.3668 | DOI Listing |
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