Maternal obesity programs the offspring to metabolic dysfunction. However, the effects of maternal obesity on skeletal muscle programming and ageing have been little explored. To determine if maternal obesity is a detriment to the progress of age-related muscle strength loss in the offspring (F), we evaluated the indicators of muscle strength, adiposity, and metabolism at young adult and senior adult ages of maternal obesity F1 (MOF) males and females from a high-fat diet-induced maternal obesity model in rat. Controls were agematched siblings whose mothers were fed a standard maternal diet (CF). Combinatorial data analysis was performed with body weight (BW), forelimb grip strength (FGS), FGS adjusted with BW, body fat, adiposity index, and serum triacylglycerols, cholesterol, glucose, insulin, and homeostatic model assessment for insulin resistance variables, to identify discriminant traits of variation among F groups. During ageing, maternal obesity caused glucose and cholesterol metabolic dysfunctions in male F, whereas adiposity-associated skeletal strength loss and fatty acid alterations were present in female offspring. In conclusion, offspring programming-ageing effects due to maternal obesity impact metabolism and skeletal muscle strength loss at later ages in a sex-dependent manner.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Affordability of family foods is associated with Nutritional Status of women with pre-school children in Addis Ababa, Ethiopia.
Sci Rep
January 2025
Global Health and Migration Unit, Department of Women's and Children Health, Uppsala University, Uppsala, 751 85, Sweden.
Malnutrition among women of reproductive age is a critical public health issue in LMICs, where undernutrition coexists with rising overweight and obesity rates. In Ethiopia, particularly among urban women, maternal and child undernutrition remains high despite efforts to combat poverty and food insecurity. This study examined the relationship between food affordability and the nutritional status of 4797 women in Addis Ababa.
View Article and Find Full Text PDFGestational diabetes and other maternal and neonatal-associated conditions could improve after bariatric surgery.
Surg Obes Relat Dis
December 2024
General Surgery Department, Bariatric Surgery Program, Hospital Privado Universitario de Córdoba, Córdoba, Argentina.
Background: Women represent 40% of patients undergoing bariatric surgery. This highlights the importance of understanding its effects on pregnancy and newborns (NBs).
Objective: To compare pregnancy and neonatal outcomes between a group of pregnant women with obesity and those who had prior bariatric surgery.
Changes in abdominal adipose tissues and ectopic fat depots during pregnancy are dissociated from gestational weight gain.
Obesity (Silver Spring)
January 2025
Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Objective: The study objective was to evaluate changes in abdominal adipose tissue and ectopic fat during pregnancy and their associations with gestational weight gain (GWG) in women with overweight/obesity.
Methods: This study was a secondary analysis of a randomized controlled trial. Magnetic resonance scans were performed during gestational week (GW) 15, GW 32, and around birth to measure abdominal subcutaneous (SAT) and visceral (VAT) adipose tissues, liver fat, and muscle fat.
Association of Dietary Patterns and Pre-pregnancy Body Mass Indices With Gestational and Birth Outcomes in Pregnant Emirati Women: A Cross-Sectional Study.
Cureus
December 2024
Pediatrics, United Arab Emirates University, Al Ain, ARE.
Background And Aim: This cross-sectional, community-based study examined the association of dietary intake of pregnant Emirati women and their pre-pregnancy body mass index (pBMI) with maternal and neonatal outcomes.
Methods: The study was conducted at tertiary hospitals in Abu Dhabi, United Arab Emirates, where 323 pregnant women reported their weekly dietary intake using the Arabic version of the food frequency questionnaire. Dietary patterns (DPs) were established using factor analysis of consumed foods followed by cluster analysis.
Acupuncture for hormonal readiness and gut microbiota in obese polycystic ovary syndrome: an open-label, randomized controlled trial.
Front Endocrinol (Lausanne)
January 2025
School of Acupuncture-Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Objective: To explore whether acupuncture combined with clomiphene can reduce the luteinizing hormone-to follicle-stimulating hormone ratio and impact the gut microbiota in patients with obese polycystic ovary syndrome.
Methods: This open-label, randomized, parallel-group controlled trial included 86 women aged 20-40 years with obese polycystic ovary syndrome and 19 healthy controls. Participants were randomly assigned to either an acupuncture combined with clomiphene group or a clomiphene-only group, with a healthy control group for comparison.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!