AI Article Synopsis
- Moderate to heavy alcohol consumption is linked to an increased risk of breast cancer, but genetic influences on this relationship, particularly among Black women, are not well understood.
- The study analyzed data from 2,889 U.S. Black women, focusing on the effects of genetic variations in ethanol metabolism genes (specifically ADH, ALDH, CYP2E1, and ALDH2) on breast cancer risk in relation to alcohol consumption.
- Significant genetic effects were found, showing that certain genetic variations are associated with higher odds of developing specific types of breast cancer in women consuming seven or more drinks per week.
Article Abstract
Background: Moderate to heavy alcohol consumption is associated with an increased risk of breast cancer. The etiologic role of genetic variation in genes involved in ethanol metabolism has not been established, with little information available among women of African ancestry.
Methods: Our analysis from the African American Breast Cancer Epidemiology and Risk (AMBER) Consortium included 2889 U.S. Black women who were current drinkers at the time of breast cancer diagnosis (N cases = 715) and had available genetic data for four ethanol metabolism genomic regions (ADH, ALDH, CYP2E1, and ALDH2). We used generalized estimating equations to calculate genetic effects, gene* alcohol consumption (≥ 7drinks/week vs. < 7/week) interactions, and joint main plus interaction effects of up to 23,247 variants in ethanol metabolism genomic regions on odds of breast cancer.
Results: Among current drinkers, 21% of cases and 14% of controls reported consuming ≥ 7 drinks per week. We identified statistically significant genetic effects for rs79865122-C in CYP2E1 with odds of ER- breast cancer and odds of triple negative breast cancer, as well as a significant joint effect with odds of ER- breast cancer (≥ 7drinks per week OR = 3.92, < 7 drinks per week OR = 0.24, p = 3.74 × 10). In addition, there was a statistically significant interaction of rs3858704-A in ALDH2 with consumption of ≥ 7 drinks/week on odds of triple negative breast cancer (≥ 7drinks per week OR = 4.41, < 7 drinks per week OR = 0.57, p = 8.97 × 10).
Conclusions: There is a paucity of information on the impact of genetic variation in alcohol metabolism genes on odds of breast cancer among Black women. Our analysis of variants in four genomic regions harboring ethanol metabolism genes in a large consortium of U.S. Black women identified significant associations between rs79865122-C in CYP2E1 and odds of ER- and triple negative breast cancer. Replication of these findings is warranted.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259046 | PMC |
| http://dx.doi.org/10.1186/s13058-023-01660-1 | DOI Listing |
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