Objective: Disinhibitory behavior during childhood and adolescence has been frequently shown to amplify the risk for substance use disorder (SUD) in adulthood. This prospective study examined the hypothesis that poor communication with parents and association with deviant peers comprise an SUD-promoting environtype which catalyzes transition of disinhibitory behavior toward SUD.
Method: Male (N = 499) and female (N = 195) youths were tracked from 10 to 12 to 30 years of age. Path analysis evaluated the patterning of disinhibitory behavior and social environment during childhood on substance use during adolescence, and antisocial personality without co-occurring SUD in early adulthood and subsequently substance use disorder (SUD).
Results: Disinhibitory behavior (SUD vulnerability) in childhood predicts antisociality without SUD (age 22) that segues to SUD (age 23-30) whereas the environtype (parents and peers) predicts substance use during adolescence which predicts antisocial personality leading to SUD. Antisociality without SUD in early adulthood mediates the association of substance use during adolescence and SUD.
Conclusion: Disinhibitory behavior and deviance-promoting social environment conjointly promote development of SUD via deviant socialization.
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http://dx.doi.org/10.1016/j.pbb.2023.173585 | DOI Listing |
Brain Struct Funct
January 2025
Behavioral Neuroscience Laboratory, Department of Psychology, Boğaziçi University, Bebek, 34342, Istanbul, Turkey.
Theta oscillations of the mammalian amygdala are associated with processing, encoding and retrieval of aversive memories. In the hippocampus, the power of the network theta oscillation is modulated by basal forebrain (BF) GABAergic projections. Here, we combine anatomical and computational approaches to investigate if similar BF projections to the amygdaloid complex provide an analogous modulation of local network activity.
View Article and Find Full Text PDFCereb Cortex
September 2024
Institute for Advanced Simulation (IAS-6), Jülich Research Centre, Wilhelm-Johnen-Straße, 52428 Jülich, Germany.
Front Synaptic Neurosci
August 2024
Centre for Research in Neuroscience, Brain Repair, and Integrative Neuroscience Program, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, QC, Canada.
Short-term plasticity is an important feature in the brain for shaping neural dynamics and for information processing. Short-term plasticity is known to depend on many factors including brain region, cortical layer, and cell type. Here we focus on vasoactive-intestinal peptide (VIP) interneurons (INs).
View Article and Find Full Text PDFJ Neurophysiol
October 2024
Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Psychol Med
September 2024
Department of Psychology, University of Konstanz, Konstanz, Germany.
Much research has focused on executive function (EF) impairments in psychopathy, a severe personality disorder characterized by a lack of empathy, antisocial behavior, and a disregard for social norms and moral values. However, it is still unclear to what extent EF deficits are present across psychopathy factors and, more importantly, which EF domains are impaired. The current meta-analysis answers these questions by synthesizing the results of 50 studies involving 5,694 participants from 12 different countries.
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