The composite lightweight porous material (TOCNF-G-LPM) based on TEMPO-oxidized cellulose nanofibril (TOCNF) and gelatin were facilely prepared by ambient pressure drying using glutaraldehyde as crosslinking agent. The influence of gelatin addition on the physicochemical properties of TOCNF-G-LPM was investigated. The long-size entangled structure of TOCNF maintained the skeleton network of TOCNF-G-LPM while gelatin can adjust the characteristics of highly porous network (porosity of 98.53%-97.40%) and light weight (density of 0.0236-0.0372 g/cm) with increasing gelatin concentration (0.2-1.0 wt%). The results of scanning electron microscopy (SEM) and confocal laser scanning microscope (CLSM) indicated that the internal structure of TOCNF-G-LPM became more ordered, uniform and denser as gelatin concentration increased. Introducing gelatin decreased water and oil absorption properties, but improved the thermal, mechanical properties and shape recovery ability of TOCNF-G-LPM at appropriate addition. Furthermore, TOCNF-G-LPM showed no significant effect on the growth and reproduction of Caenorhabditis elegans (C. elegans), confirming a good biocompatibility.
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http://dx.doi.org/10.1016/j.foodchem.2023.136497 | DOI Listing |
Curr Med Chem
January 2025
Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva, 384012, India.
Aims: This study aimed to develop Imatinib Mesylate (IMT)-loaded Poly Lactic-co-Glycolic Acid (PLGA)-D-α-tocopheryl polyethylene glycol succinate (TPGS)- Polyethylene glycol (PEG) hybrid nanoparticles (CSLHNPs) with optimized physicochemical properties for targeted delivery to glioblastoma multiforme.
Background: Glioblastoma multiforme (GBM) is the most destructive type of brain tumor with several complications. Currently, most treatments for drug delivery for this disease face challenges due to the poor blood-brain barrier (BBB) and lack of site-specific delivery.
ACS Pharmacol Transl Sci
January 2025
Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Ceará 60714-903, Brazil.
Leishmaniasis is a chronic inflammatory zoonotic illness caused by protozoan flagellates belonging to the genus. Current data suggest that over 1 billion people worldwide are susceptible to infection, primarily in tropical and subtropical countries, where up to 2 million new cases are reported annually. Therefore, the development of a vaccine is crucial to combating this disease.
View Article and Find Full Text PDFACS Pharmacol Transl Sci
January 2025
Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, 48149 Münster, Germany.
This study presents a novel series of -acylated 1,2,4-triazol-5-amines and 1-pyrazol-5-amines, featuring a pyrazin-2-yl moiety, developed as covalent inhibitors of thrombin. These compounds demonstrated potent inhibitory activity, with derivatives and achieving IC values as low as 0.7 and 0.
View Article and Find Full Text PDFHeliyon
January 2025
Department of Food Science and Technology, College of Agriculture, Isfahan University of Technology, 84156-83111, Isfahan, Iran.
Packaging films based on natural biopolymers often suffer from inadequate barrier and mechanical properties. To address these challenges, multilayer films have emerged as potential solutions. In this study, we prepared bilayer films using bitter vetch seed protein (BVSP) and polylactic acid (PLA).
View Article and Find Full Text PDFFood Sci Nutr
January 2025
Department of Food Science and Technology, Faculty of Agriculture Urmia University Urmia Iran.
Steam injection, especially in a superheated state, increases the rate of heat transfer and improves the quality of the baked products. In this research, different baking methods (forced convention, superheated steam, and superheated steam-assisted) at different temperatures (140°C, 160°C, 180°C) were applied to produce a new formulated rice cake containing acorn flour and inulin. The findings revealed that the level of moisture inside the oven directly influences the volume of the cake.
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