AI Article Synopsis
- * Out of 201 patients treated with tenofovir (alone or with peginterferon), 50 experienced ALT flares, with 74% classified as moderate or severe, which were linked to significant HBsAg reductions compared to those without flares.
- * Results indicate that severe ALT flares lead to quicker decreases in HBsAg levels, suggesting flare intensity could be an important factor in assessing responses to hepatitis B treatments.
Article Abstract
Introduction: We aimed to determine whether the intensity of alanine aminotransferase (ALT) flares during antiviral therapy is associated with the level of hepatitis B surface antigen (HBsAg) decline.
Methods: Quantitative HBsAg was determined during tenofovir monotherapy or tenofovir plus peginterferon alfa-2a in 201 participants with hepatitis B e antigen-positive or -negative chronic hepatitis B. A multivariable analysis identified factors associated with a shorter time to reduction in HBsAg.
Results: Fifty flares occurred during treatment of which 74% were moderate (ALT >5-10 × upper limit of normal) or severe (ALT >10 × upper limit of normal). These flares were associated with greater HBsAg decline compared with no flares. Significantly faster times to HBsAg decline >1 log 10 IU ( P = 0.04) and to HBsAg level <100 IU/mL ( P = 0.01) were observed with severe flares.
Discussions: Flare severity is a potentially important factor associated with shorter time to HBsAg reduction. These findings can be useful when evaluating HBsAg response to evolving hepatitis B virus therapies.
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| http://dx.doi.org/10.14309/ajg.0000000000002355 | DOI Listing |
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