Physiology in Perspective.

This issue of features four excellent review articles that highlight current research and discuss untapped areas for future work across a range of topics in physiology. First, we explore the impact that the loss of the Y chromosome in white blood cells has on men's health. Next, we discuss the pathophysiological roles of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) in chronic inflammation. Third, we discuss how certain animals remain hydrated in seawater. Finally, we present on the systemic reprogramming of endothelial cell signaling in metastasis and cachexia.