AI Article Synopsis
- A new method was developed that allows for the reaction of 3-(2-isocyanoethyl)indoles with 1-sulfonyl-1,2,3-triazoles without the need for a catalyst.
- This process, called dearomative spirocyclization, efficiently creates polycyclic indolines that contain a spiro-α-carboline structure.
- The reaction takes place in a single step through thermal conditions, yielding the desired compounds in moderate to high amounts.
Article Abstract
A catalyst-free cascade reaction of 3-(2-isocyanoethyl)indoles and 1-sulfonyl-1,2,3-triazoles was realized. This dearomative spirocyclization provided an efficient protocol to synthesize a series of polycyclic indolines bearing spiro-α-carboline in moderate to high yields in one step under thermal reaction conditions.
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| http://dx.doi.org/10.1021/acs.joc.3c00800 | DOI Listing |
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