Engineering a potent boron-10-enriched polymeric nanoparticle for boron neutron capture therapy.

Boron neutron capture therapy (BNCT) is a promising cancer treatment that eliminates tumor cells by triggering high-energy radiation within cancer cells. evaluation of poly(vinyl alcohol)/boric acid crosslinked nanoparticles (PVA/BA NPs) for BNCT. PVA/BA NPs were synthesized and intravenously injected into tumor-bearing mice for BNCT. The boron uptake of PVA/BA NPs in tumor cells was 70-fold higher than the required boron uptake for successful BNCT. In an study, PVA/BA NPs showed a 44.29% reduction in tumor size compared with clinically used boronophenylalanine for oral cancer in a murine model. PVA/BA NPs exhibited effective therapeutic results for oral cancer treatments in BNCT.