Morphological changes of the endothelium were induced by acute elevation of intravascular pressure in the normal perfused rabbit aorta from 100 to 250 mm Hg. The number of argyrophilic cells and stigmata per 1 mm2 of the luminal surface has significantly increased. The acute rise in intravascular pressure was followed by a 2-fold and 20-fold increase in the uptake of 125I-labelled low density lipoproteins in intact endothelial areas and denudation areas, respectively. The acute rise in intravascular pressure is suggested to increase the uptake of 125I-labelled LDL in the areas of damaged, but not in the areas of intact endothelium.
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