AI Article Synopsis
- The study aimed to understand the link between different types of adiposity (metabolically unfavorable and favorable) and the risk of aggressive prostate cancer using Mendelian randomization.
- Researchers analyzed data from the PRACTICAL consortium, including over 15,000 aggressive prostate cancer cases, to evaluate the genetic influence of various adiposity traits on cancer risk.
- The findings indicated no strong associations between either type of adiposity or body mass index (BMI) and aggressive prostate cancer, suggesting metabolic factors aren't the primary influencers of prostate cancer risk, but further research is needed to investigate other potential links.
Article Abstract
Background: The associations of adiposity with aggressive prostate cancer risk are unclear. Using two-sample Mendelian randomization, we assessed the association of metabolically unfavourable adiposity (UFA), favourable adiposity (FA) and for comparison body mass index (BMI), with prostate cancer, including aggressive prostate cancer.
Methods: We examined the association of these genetically predicted adiposity-related traits with risk of prostate cancer overall, aggressive and early onset disease using outcome summary statistics from the PRACTICAL consortium (including 15,167 aggressive cases).
Results: In inverse-variance weighted models, there was little evidence that genetically predicted one standard deviation higher UFA, FA and BMI were associated with aggressive prostate cancer [OR: 0.85 (95% CI:0.61-1.19), 0.80 (0.53-1.23) and 0.97 (0.88-1.08), respectively]; these associations were largely consistent in sensitivity analyses accounting for horizontal pleiotropy. There was no strong evidence that genetically determined UFA, FA or BMI were associated with overall prostate cancer or early age of onset prostate cancer.
Conclusions: We did not find differences in the associations of UFA and FA with prostate cancer risk, which suggest that adiposity is unlikely to influence prostate cancer via the metabolic factors assessed; however, these did not cover some aspects related to metabolic health that may link obesity with aggressive prostate cancer, which should be explored in future studies.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469819 | PMC |
| http://dx.doi.org/10.1002/cam4.6220 | DOI Listing |
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