Cytomegalovirus (CMV) ulcerations are rare clinical entities, but their occurrence is favored in immunocompromised patients who present a favorable environment for opportunistic infections. We describe the case of a patient treated for a systemic lupus erythematosus suffering from deep oral ulcerations. The case illustrates the complexity of establishing a precise etiological diagnosis of CMV lesions, as the diagnostic hypothesis can be varied: related to an immunodeficiency disorder or drug-induced toxidermia.
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http://dx.doi.org/10.1002/ccr3.7459 | DOI Listing |
Clin Case Rep
June 2023
Department of Oral Mucosal Pathology, AP-HP Groupe Hospitalier Pitié-Salpêtrière University of Paris Paris France.
Cytomegalovirus (CMV) ulcerations are rare clinical entities, but their occurrence is favored in immunocompromised patients who present a favorable environment for opportunistic infections. We describe the case of a patient treated for a systemic lupus erythematosus suffering from deep oral ulcerations. The case illustrates the complexity of establishing a precise etiological diagnosis of CMV lesions, as the diagnostic hypothesis can be varied: related to an immunodeficiency disorder or drug-induced toxidermia.
View Article and Find Full Text PDFInt J Hematol
May 2023
Department of Oral and Maxillofacial Surgery, Osaka General Hospital of West Japan Railway Company, Osaka, Japan.
Front Microbiol
June 2022
Department of Special Medicine, School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, China.
Case Rep Dent
September 2020
Division of Oral and Maxillofacial Surgery, Tohoku University Graduate School of Dentistry, 4-1, Seiryo-machi, Aoba-Ku, Sendai 980-8575, Japan.
We report a case of cytomegalovirus- (CMV-) induced buccal ulcer in a patient with nephrotic syndrome. An 82-year-old man with membranous nephropathy was on immunosuppressive therapy presented with an ulcer in the oral cavity and was hospitalized. Intraoral examination revealed an inflamed and painful ulcer on the left buccal mucosa.
View Article and Find Full Text PDFExp Mol Pathol
April 2013
Laboratory for Developmental Genetics, USC, Los Angeles, CA 90089-0641, USA.
Mucoepidermoid carcinoma (MEC) is the most common malignant tumor originating in major and minor salivary glands (SGs). Although the precise multifactorial etiology of human SG-MEC is largely unknown, we have recently shown that cytomegalovirus (CMV) is an important component of MEC tumorigenesis. Despite the well-documented overexpression of the EGFR → ERK signaling pathway in SG-MEC, there has been limited to no clinical success with inhibition of this pathway.
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