AI Article Synopsis
- The study aims to create a device that simulates human arterial blood vessels using fluid shear stress and cyclic stretch to replicate blood flow and pressure conditions.
- The device allows for real-time observation of how endothelial cells react to various flow patterns and stretching, showing changes in cell shape and protein distribution.
- By understanding these cellular responses to physical forces, the research could lead to better prevention and treatment methods for cardiovascular diseases.
Article Abstract
The objective of this study is to develop a device to mimic a microfluidic system of human arterial blood vessels. The device combines fluid shear stress (FSS) and cyclic stretch (CS), which are resulting from blood flow and blood pressure, respectively. The device can reveal real-time observation of dynamic morphological change of cells in different flow fields (continuous flow, reciprocating flow and pulsatile flow) and stretch. We observe the effects of FSS and CS on endothelial cells (ECs), including ECs align their cytoskeleton proteins with the fluid flow direction and paxillin redistribution to the cell periphery or the end of stress fibers. Thus, understanding the morphological and functional changes of endothelial cells on physical stimuli can help us to prevent and improve the treatment of cardiovascular diseases.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251125 | PMC |
| http://dx.doi.org/10.1016/j.isci.2023.106927 | DOI Listing |
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