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Call to action for Clinicians in the South-East Asian Regions on Primary Prevention of Diabetes in people with Prediabetes- A Consensus statement.
Diabetes Res Clin Pract
January 2025
Department of Cardiovascular and Metabolic Diseases, Istituto Ricerca Cura Carattere Scientifico Multimedica, Sesto, San Giovanni (MI), Italy.
Primary prevention of diabetes still remains as an unmet challenge in a real world setting. While, translational programmes have been successful in the developed nations, the prevailing social and economic inequities in the low and middle income countries, fail to integrate diabetes prevention into their public health systems. The resulting exponential increase in the prevalence of diabetes and the cost of treatment has put primary prevention in the back seat.
View Article and Find Full Text PDFPersistent organic pollutants and fatty acids in humpback whales: Antarctic and Chilean feeding and Brazilian breeding sites.
Sci Total Environ
January 2025
Instituto Oceanográfico, Universidade de São Paulo, Praça do Oceanográfico, 191, São Paulo, SP 05508-120, Brazil.
Article Synopsis
- The study examined the fatty acid profiles and persistent organic pollutant (POP) levels in humpback whales from different regions of the Southern Ocean, Chile, and Brazil.
- Significant differences were found in the fatty acid compositions, with whales in the Strait of Magellan showing a diet high in higher trophic level prey, while those from the Antarctic Peninsula and Brazil reflected a krill-based diet.
- Elevated concentrations of pollutants, especially PCBs, were observed in whales from the Strait of Magellan, indicating a connection between their dietary habits and exposure to contaminants.
Introducing the Special Issue on Label-Free Quantitative Phase Imaging Honoring Prof. Gabriel Popescu, a Pioneer in Biomedical Optics.
J Biomed Opt
June 2024
Morgridge Institute for Research, Madison, Wisconsin, United States.
The editorial introduces the JBO special issue honoring Prof. Gabriel Popescu, Pioneer in Biomedical Optics.
View Article and Find Full Text PDFCOMPARABLE OUTCOMES AFTER BUSULFAN- OR TREOSULFAN-BASED CONDITIONING FOR ALLO-HSCT IN CHILDREN WITH ALL-RESULTS OF FORUM.
Blood Adv
November 2024
Ospedale Bambino Gesù, Rome, Italy.
The superiority of TBI-based versus chemotherapy-conditioning for allo-HSCT in children with ALL has been established in the international, prospective phase-III FORUM study (#NCT01949129), randomizing 417 patients ≤ 18 years at diagnosis (4-21 years at HSCT) in CR, transplanted from HLA-matched sibling or unrelated donors. Due to the unavailability of TBI in some regions and to accommodate individual contraindications, this study reports the pre-specified comparison of outcomes of patients receiving busulfan-based (BU) or treosulfan-based (TREO) regimens from 2013 to 2018. 180 and 128 patients (median age 9.
View Article and Find Full Text PDFEpidemiological characterization of rare diseases in Brazil: A retrospective study of the Brazilian Rare Diseases Network.
Orphanet J Rare Dis
October 2024
Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, Porto Alegre, RS, 90035-903, Brazil.
Article Synopsis
- - The Brazilian Rare Diseases Network (RARAS) was established in 2020 to conduct a nationwide epidemiological survey on rare diseases (RDs) in Brazil, addressing the lack of comprehensive national data since the Comprehensive Care Policy for RDs began in 2014.
- - A total of 12,530 patients were surveyed, with a median age of 15 years; significant findings included that 63.2% had confirmed diagnoses, primarily of phenylketonuria, cystic fibrosis, and acromegaly, and average diagnostic delays lasting 5.4 years.
- - The majority of diagnoses and treatments were funded by the Public Health System, with notable rates of hospitalization (44.5%) and a mortality rate
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