AI Article Synopsis
- Mycoplasma pneumoniae is a key cause of community-acquired pneumonia in kids, but how it causes severe illness is not well understood.
- A study analyzed the microbiomics and immune responses in 41 children with Mycoplasma pneumoniae pneumonia using samples from both sides of their lungs.
- Findings suggest that the severity of MPP is linked to the host's immune response rather than differences in microbial load, highlighting the potential for targeted treatment strategies based on immune mechanisms.
Article Abstract
Introduction: Mycoplasma pneumoniae (MP) is a major pathogen of community-acquired pneumonia in children. However, the specific pathogenesis of the progression of Mycoplasma pneumoniae pneumonia (MPP) is unclear. We aimed to reveal the landscape of microbiota and the host immune response in MPP.
Methods: This self-controlled study analyzed the microbiome and transcriptome of bronchoalveolar lavage fluid (BALF) from the severe side (SD) and opposite side (OD) of 41 children with MPP from January to December 2021 and revealed the differences of the peripheral blood neutrophil function among children with mild MPP, severe MPP, and healthy children through transcriptome sequencing.
Results: The MP load or the pulmonary microbiota had no significant difference between the SD group and OD group, and the deterioration of MPP was related to the immune response, especially the intrinsic immune response.
Discussion: The immune response plays a role in MPP, which may inform treatment strategies for MPP.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250694 | PMC |
| http://dx.doi.org/10.3389/fimmu.2023.1189647 | DOI Listing |
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