The emergence and spread of carbapenem resistance in Gram-negative bacilli such as , , , and through the production of carbapenemases is a global phenomenon. It threatens patient care and leads to therapeutic impasses. This study aims to genotypically determine the prevalence of the most frequent carbapenemase genes among multidrug-resistant strains isolated from patients at a biomedical analysis laboratory. A total of fifty-three unduplicated strains isolated from patient samples with a multidrug-resistant (MDR) profile were subjected to polymerase chain reaction (PCR) testing for carbapenem resistance genes. This study allowed us to identify fifteen strains carrying resistance genes among the fifty-three strains. All fifteen strains produced the metallo--lactamase enzymes; this represents a rate of 28.30% of study strains. Among these strains, ten carried the NDM resistance gene, NDM and VIM genes were detected in three strains and VIM was identified in two strains of . However, carbapenemases A (KPC and IMI), D (OXA-48), and IMP were not detected in the strains studied. Thus, NDM and VIM are the main carbapenemases detected in the strains in our study.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256439 | PMC |
| http://dx.doi.org/10.1155/2023/4813225 | DOI Listing |
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