Huangqi Guizhi Wuwu decoction improves hemorheology and inhibits inflammatory response after PCI for acute myocardial infarction.

Objective: To determine the impact of Huangqi Guizhi decoction of five ingredients on hemorheology and inflammatory factors in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI).

Methods: A total of 111 cases of AMI treated in Tongchuan Hospital of Traditional Chinese Medicine from February 2019 to February 2022 were analyzed retrospectively. Among them, 47 patients who received routine treatment were assigned to the control group, while those who received Huangqi Guizhi decoction of five ingredients in addition to the treatment of the control group were assigned to the study group. The clinical efficacy in the two groups was evaluated after therapy. The two groups were compared as to changes in serum inflammatory factors [tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6)] before and after therapy. The two groups were also compared as to differences in fibrinogen, plasma viscosity, whole blood low-shear viscosity (WBLSV), and whole blood high-shear viscosity (WBHSV) before and after therapy. Left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic diameter (LVESD), and left ventricular ejection fraction (LVEF) in the two groups were evaluated. In addition, the two groups were compared as to incidence of major adverse cardiovascular events (MACE) in 6 months. Logistic regression analysis was conducted to analyze the risk factors for MACE.

Results: The study group showed a significantly higher treatment efficacy than the control group (P < 0.05). After therapy, the study group had significantly lower levels of TNF-α, hs-CRP, IL-6, fibrinogen, plasma viscosity, WBLSV, and WBHSV than the control group (all P < 0.05), and showed lower LVEDD and LVESD levels and a higher LVEF level than the control group. According to logistic regression analysis, age, history of diabetes mellitus (TM), New York Heart Association (NYHA) classification, hsCPR, and LVEF were independent risk factors for MACE (all P < 0.05).

Conclusion: Huangqi Guizhi decoction of five ingredients contributes to higher efficacy in AMI and has the effects of inhibiting the inflammation and hemorheology of patients. In addition, age, history of TM, NYHA classification, hsCPR, and LVEF were independent risk factors for MACE.