Cities are at the forefront of European and international climate action. However, in many cities, the ever-growing urban population is putting pressure on settlement and infrastructure development, increasing attention to urban planning, infrastructure and buildings. This paper introduces a set of quantification approaches, capturing impacts of urban planning measures in three fields of action: sustainable building, transport and redensification. The quantification approaches have been developed to account for different levels of data availability, thus providing users with quantification approaches that are applicable across cities. The mitigation potentials of various measures such as a modal shift, the substitution of building materials with wood, and different redensification scenarios were calculated. The substitution of conventional building materials with wood was analyzed as having a high mitigation potential. Building construction, in combination with urban planning and design, are key drivers for mitigating climate change in cities. Given the data heterogeneity among cities, mixed quantification approaches could be defined and the measures and policy areas with the greatest climate mitigation potential identified.
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http://dx.doi.org/10.1016/j.heliyon.2023.e16733 | DOI Listing |
Cell fate decisions, such as proliferation, differentiation, and death, are driven by complex molecular interactions and signaling cascades. While significant progress has been made in understanding the molecular determinants of these processes, historically, cell fate transitions were identified through light microscopy that focused on changes in cell morphology and function. Modern techniques have shifted towards probing molecular effectors to quantify these transitions, offering more precise quantification and mechanistic understanding.
View Article and Find Full Text PDFOrthod Fr
January 2025
Laboratoire Forme et Croissance du Crâne, Institut Imagine, 24 boulevard du Montparnasse, 75015 Paris, France
Introduction: Facial asymmetry, present in all human faces at varying degrees, plays a critical role in clinical fields such as orthodontics, orthognathic and plastic surgeries, and craniofacial reconstruction. Accurate quantification of facial asymmetry is essential for diagnosis, treatment planning, and post-surgical evaluation.
Material And Methods: This article examines contemporary methods for quantifying facial asymmetry, including two-dimensional (2D) and three-dimensional (3D) landmark-based approaches, surface curvature analysis, and advanced image-based techniques.
Orthod Fr
January 2025
Service de Médecine bucco-dentaire, AP-HP, Hôpital Pitié Salpêtrière, 83 boulevard de l’Hôpital, 75013 Paris, France
Introduction: The diagnostic approach to facial asymmetries is classically based, in addition to the clinical examination, on a cephalometric analysis carried out on a frontal radiography. Planning of orthognathic surgery requires a three-dimensional (3D) examination to visualize deformities. Nevertheless, the use of cephalometric analysis on 3D imaging remains clinically modest.
View Article and Find Full Text PDFJ Proteome Res
January 2025
Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, 69120 Heidelberg, Germany.
The first step in bottom-up proteomics is the assignment of measured fragmentation mass spectra to peptide sequences, also known as peptide spectrum matches. In recent years novel algorithms have pushed the assignment to new heights; unfortunately, different algorithms come with different strengths and weaknesses and choosing the appropriate algorithm poses a challenge for the user. Here we introduce PeptideForest, a semisupervised machine learning approach that integrates the assignments of multiple algorithms to train a random forest classifier to alleviate that issue.
View Article and Find Full Text PDFChembiochem
January 2025
Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Materia Medica, State Key Laboratory of Bioactive Substances and Function of Natural Medicine, 1 Xian Nong Tan Street, 100050, Beijing, CHINA.
Bacterial infections, particularly those caused by drug-resistant bacteria, represent a pressing global health challenge. During the interaction between pathogen infection and host defense, bacterial infections initiate the host's immune response, which involves the activation of proteases that play a critical role in antibacterial defense. Granzyme B (GzmB), a key immune-related biomarker associated with cytotoxic T lymphocytes (CTLs), plays a pivotal role in this process.
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