A 72-year-old male presented with a fever and altered mental status. While initially diagnosed with sepsis due to cholangitis, he continued to decline and had seizures that complicated the course. After extensive workup, he was found to have anti-thyroid peroxidase antibodies and diagnosed with steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT). He showed remarkable improvement with glucocorticoids and intravenous immunoglobulins. SREAT is a rare autoimmune encephalopathy characterized by elevated serum titers of antithyroid antibodies. SREAT needs to be listed as a differential diagnosis in a patient with encephalopathy of unclear causes, and the presence of antithyroid antibodies is a hallmark of the entity.
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| http://dx.doi.org/10.7759/cureus.38826 | DOI Listing |
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View Article and Find Full Text PDFArticle Synopsis
- Steroid-responsive encephalopathy associated with thyroiditis (SREAT) is a rare autoimmune disorder that causes cognitive dysfunction, often going unnoticed in medical settings.
- A case report highlights a male patient who suffered from various neuropsychiatric symptoms linked to SREAT, stressing the importance of early diagnosis.
- The report advocates for recognizing SREAT in patients with unexplained symptoms, showcases the role of steroids in treatment, and emphasizes the need for better diagnostic criteria and personalized treatment plans to improve patient care.
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