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| http://dx.doi.org/10.1016/j.hbpd.2023.06.005 | DOI Listing |
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Segmental MRI pituitary and hypothalamus volumes post Fontan: An analysis of the Australian and New Zealand Fontan registry.
Int J Cardiol Congenit Heart Dis
December 2024
Paediatric Diabetes and Endocrine Service, Starship Child Health, Te Toka Tumai Auckland Te Whatu Ora, Auckland, New Zealand.
Objective: Short stature, central hypothyroidism and infertility are common in those with a Fontan circulation. Given that the Fontan circulation often results in hepatic portal venous congestion, we hypothesize that the hypothalamic-pituitary portal circulation is also affected, contributing to subsequent hypothalamic-pituitary axis dysfunction.
Methods: MRI data from the Australian and New Zealand Fontan Registry (86 cases) was compared to 86 age- and sex-matched normal published controls.
A retrospective review of sildenafil in the Australia and New Zealand Fontan registry: indications and treatment responses.
Int J Cardiol Congenit Heart Dis
June 2024
University of Sydney, Sydney, Australia.
Introduction: Rates of morbidity and mortality are high in the setting of Fontan physiology and effective medical therapies are not well-established. Clinical trials assessing phosophodiesterase-5-inhibitors, such as sildenafil, have not demonstrated major benefit in patients with a Fontan-type circulation but have only included stable, well-functioning people.
Methods: We sought to retrospectively characterize the people followed by the ANZ Fontan Registry prescribed sildenafil >30 days post Fontan-surgery.
The impact of dominant ventricle morphology and additional ventricular chamber size on clinical outcomes in patients with Fontan circulation.
Cardiol Young
October 2024
Pediatric Cardiology, Department of Woman and Child's Health, University of Padova, Padova, Italy.
Objectives: The functional roles of ventricular dominance and additional ventricular chamber after Fontan operation are still uncertain. We aim to assess and correlate such anatomical features to late clinical outcomes.
Methods: Fontan patients undergoing cardiac MRI and cardiopulmonary exercise test between January 2020 and December 2022 were retrospectively reviewed.
Ultrasonographic placental edematous changes as predictive markers of unplanned preterm birth in post-Fontan pregnancies: A single-center observational study.
J Obstet Gynaecol Res
December 2024
Department of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, Japan.
Aim: Fontan surgery is a palliative procedure commonly performed for functional single-ventricle heart diseases. Fontan circulation is characterized by elevated central venous pressure and low cardiac output. It causes placental hypoxia, which could lead to poor obstetric outcomes.
View Article and Find Full Text PDFEffect of maneuvers, diuresis, and fluid administration on ultrasound-measured liver stiffness after Fontan.
Hepatol Commun
October 2024
Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Article Synopsis
- The study aimed to examine how various stress maneuvers affect liver stiffness measurements (LSMs) in patients with Fontan circulation compared to healthy individuals.
- Ten post-Fontan patients and ten healthy controls underwent ultrasound measurements at baseline and after performing various maneuvers like exercise and fluid administration.
- Results showed that post-Fontan patients had higher LSMs at baseline and during all maneuvers compared to controls, but diuresis significantly reduced liver stiffness in both groups, with a stronger effect noted in Fontan patients.
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