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Flegel's Disease A Very Rare Skin Disease: A Case Report of Mother and Daughter in a Family.
Mymensingh Med J
January 2025
Dr Md Mostaque Mahmud, Associate Professor, Department of Dermatology & Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh; E-mail:
Flegel's disease (FD) or hyperkeratosis lenticularis perstans (HLP) is an extremely exceptional skin disease typified by hyper-keratotic papules usually found on the lower extremities. Only the histopathological study is the confirmatory test for diagnosis this disease. The treatment of Flegel's disease is not yet settled as a standard one.
View Article and Find Full Text PDFCase report: Abrocitinib: a potential therapeutic option for lichen amyloidosis associated with atopic dermatitis.
Front Immunol
November 2024
School of Medicine, Tongji University, Shanghai, China.
Lichen amyloidosis (LA) is a predominant type of primary cutaneous amyloidosis that is characterized by persistent and intense skin itching. Although multiple therapeutics strategies are available for its treatment, there is no standard treatment so far. Abrocitinib, an oral small-molecule Janus kinase 1 inhibitor, has been authorized for the treatment of severe atopic dermatitis (AD) and can also provide rapid relief from pruritus.
View Article and Find Full Text PDFAtypical presentation of anti-small ubiquitin-like modifier 1 and melanoma differentiation-associated gene 5 antibody positive dermatomyositis presenting with significant inflammatory myopathy on biopsy and normal creatine kinase levels: A case report.
SAGE Open Med Case Rep
November 2024
Department of Rheumatology, University of California San Francisco Fresno, Fresno, CA, USA.
Article Synopsis
- Idiopathic inflammatory myopathies involve chronic inflammation of skeletal muscle and include subtypes like dermatomyositis, polymyositis, and necrotizing autoimmune myopathies.
- A 19-year-old female case highlights an atypical presentation of dermatomyositis, where she exhibited classic symptoms but had normal creatinine kinase levels and severe inflammatory myopathy on biopsy.
- This case illustrates the need to rely on comprehensive clinical evaluations, as laboratory results may not always align with a patient's physical presentation.
Acneiform lesions in a 57-year-old woman.
Int J Dermatol
November 2024
Department of Dermatology, Rush University Medical Center, Chicago, Illinois, USA.
A 57-year-old woman on leflunomide with a history of chronic obstructive pulmonary disease and rheumatoid arthritis presented with multiple flesh-colored to hyperpigmented dome-shaped papules, scattered comedones, and underlying scarring on bilateral cheeks and chin. These dermatologic manifestations, laboratory evaluation, and punch biopsy led to a final diagnosis of acneiform or comedonal discoid lupus erythematosus (ACDLE). For patients with acneiform or comedonal lesions, ACDLE should be considered if the lesions do not improve with conventional treatment for acne vulgaris.
View Article and Find Full Text PDFManagement of dermatosis papulosa nigra: a systematic review.
Int J Dermatol
October 2024
Department of Dermatology, LSU Health Sciences Center-New Orleans School of Medicine, New Orleans, LA, USA.
Article Synopsis
- Dermatosis papulosa nigra (DPN) is a benign skin condition characterized by hyperpigmented, pedunculated papules, primarily affecting individuals with darker skin tones, and can lead to discomfort and distress.
- This study reviews existing literature on treatment options for DPN, encompassing 17 relevant publications, including various study types like cohort and randomized controlled trials.
- Treatment methods include excision, curettage, cryotherapy, and laser therapies, but may cause side effects like postinflammatory hyperpigmentation; treatment strategies should be tailored to individual factors such as skin type, costs, and potential adverse effects.
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