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A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease.
Immunity
January 2025
Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; St Vincent's Clinical School, UNSW Sydney, Sydney, NSW, Australia. Electronic address:
The unexplained association between infection and autoimmune disease is strongest for hepatitis C virus-induced cryoglobulinemic vasculitis (HCV-cryovas). To analyze its origins, we traced the evolution of pathogenic rheumatoid factor (RF) autoantibodies in four HCV-cryovas patients by deep single-cell multi-omic analysis, revealing three sources of B cell somatic mutation converged to drive the accumulation of a large disease-causing clone. A method for quantifying low-affinity binding revealed recurring antibody variable domain combinations created by V(D)J recombination that bound self-immunoglobulin G (IgG) but not viral E2 antigen.
View Article and Find Full Text PDFCarbothermal Shock Synthesis of Lattice Oxygen-Mediated High-Entropy FeCoNiCuMo-O Electrocatalyst with a Fast Kinetic, High Efficiency, and Stable Oxygen Evolution Reaction.
Nano Lett
January 2025
Shenzhen Institute for Advanced Study, University of Electronic Science and Technology of China, Shenzhen 518110, China.
Efficient oxygen evolution reaction (OER) catalysts with fast kinetics, high efficiency, and stability are essential for scalable green production of hydrogen. The rational design and fabrication of catalysts play a decisive role in their catalytic behavior. This work presents a high-entropy catalyst, FeCoNiCuMo-O, synthesized via carbothermal shock.
View Article and Find Full Text PDFAchieving advanced hydrogen evolution under large current density using an amorphous/crystalline core-shell electrocatalyst of a-NiCoP/CoP.
Dalton Trans
January 2025
School of Materials Science and Engineering, China University of Petroleum, Qingdao, 266580, PR China.
Non-precious transition metal-based electrocatalysts with high activities are promising candidates for substituting Pt- or Ru-based electrocatalysts in hydrogen evolution. In this study, we propose core-shell engineering to combine the amorphous NiCoP and crystalline CoP (a-NiCoP/CoP@NF), which requires an ultra-low overpotential of only 26 mV to achieve the benchmark current density of 10 mA cm. Furthermore, it achieves an industrial-level hydrogen evolution current density of 500 mA cm with excellent stability.
View Article and Find Full Text PDFSupramolecular Combination Chemotherapy: Directly Inducing Immunogenic Cell Death To Inhibit Tumor Metastasis via Host-Guest Interactions.
ACS Appl Mater Interfaces
January 2025
Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, P. R. China.
Tumor metastasis is a difficult clinical problem to solve due to tumor heterogeneity and the emergence of antiapoptotic clones driven by tumor evolution. Clinical combination chemotherapy remains a standard treatment for solid metastasis tumors but with worse treatment efficiency. It is worth exploring a high-efficiency and low-side-effect therapeutic method to solve solid metastases.
View Article and Find Full Text PDFThe Benefit of Evolution of Pesticide Tolerance Is Overruled under Combined Stressor Exposure due to Synergistic Stressor Interactions.
Environ Sci Technol
January 2025
Laboratory of Evolutionary Stress Ecology and Ecotoxicology, University of Leuven, Charles Deberiotstraat 32, 3000 Leuven, Belgium.
Despite pleas to consider both evolutionary and multistressor climate change perspectives to improve ecological risk assessment, the much needed combination of both perspectives is largely missing. This is especially important when evaluating the costs of the evolution of genetic tolerance to pollutants as these costs may become visible only under combined exposure to the pollutant and warming due to energetic constraints. We investigated the costs of chlorpyrifos tolerance in when sequentially exposed to 4-day pesticide treatments and 4-day heat spike treatments.
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