AI Article Synopsis
- - The study analyzed the effectiveness of receiving a fourth dose of the mRNA-1273 vaccine compared to only three doses in people aged 50 and older, involving nearly 357,000 participants from Kaiser Permanente Southern California.
- - Results showed that the fourth dose significantly improved protection against SARS-CoV-2 infection (25.9% more effective), COVID-19 hospitalization (67.3% more effective), and death from COVID-19 (72.5% more effective).
- - However, the effectiveness of the fourth dose decreased over time, particularly 2-4 months after vaccination, indicating that while four doses offer better protection, the level of effectiveness can vary and diminish in various demographic groups.
Article Abstract
We evaluated relative vaccine effectiveness (rVE) of 4- vs. 3-dose mRNA-1273 against SARS-CoV-2 infection, and COVID-19 hospitalization and death in immunocompetent adults aged ≥50 years at Kaiser Permanente Southern California. We included 178,492 individuals who received a fourth dose of mRNA-1273, and 178,492 randomly selected 3-dose recipients who were matched to 4-dose recipients by age, sex, race/ethnicity, and third dose date. Adjusted 4- vs. 3-dose rVE against SARS-CoV-2 infection, COVID-19 hospitalization, and COVID-19 hospitalization death were 25.9 % (23.5 %, 28.2 %), 67.3 % (58.7 %, 74.1 %), and 72.5 % (-35.9 %, 95.2 %), respectively. Adjusted rVE against SARS-CoV-2 infection ranged between 19.8 % and 39.1 % across subgroups. Adjusted rVE against SARS-CoV-2 infection and COVID-19 hospitalization decreased 2-4 months after the fourth dose. Four mRNA-1273 doses provided significant protection against COVID-19 outcomes compared with 3 doses, consistent in various subgroups of demographic and clinical characteristics, although rVE varied and waned over time.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239903 | PMC |
| http://dx.doi.org/10.1016/j.vaccine.2023.06.016 | DOI Listing |
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