AI Article Synopsis
- Systemic sarcoidosis can cause serious heart issues, including heart failure and arrhythmias, with limited data on how it relates to valvular heart disease (VHD).
- A study of 406,315 sarcoidosis patients found 5.1% also had VHD, with mitral disease being the most common, followed by aortic and tricuspid diseases.
- Patients with sarcoidosis and VHD face higher hospital costs and worse outcomes, especially with tricuspid disease linked to increased mortality, highlighting the importance of monitoring and managing these conditions together.
Article Abstract
Systemic sarcoidosis can lead to heart failure, conduction abnormalities and ventricular arrhythmias although data on concomitant valvular heart disease (VHD) is limited. We reported the prevalence and outcomes of VHD in systemic sarcoidosis. A retrospective cohort study was conducted using National Inpatient Sample between 2016 and 2020 with respective ICD-10-CM codes. 406,315 patients were hospitalized with sarcoidosis, out of which 20,570 had comorbid VHD (5.1%). Mitral disease was most common (2.5%), followed by aortic, and tricuspid disease. Tricuspid disease was associated with increased mortality in sarcoidosis (OR 1.6, 95% CI, 1.1-2.6, P = 0.04), while aortic disease was associated with higher mortality in only 31-50 years age cohort. Patients with sarcoidosis and VHD have higher hospitalization charges and lower or similar valvular intervention rates than those without sarcoidosis. VHD has a prevalence of 5% in sarcoidosis, predominantly affecting mitral and aortic valves. Underlying VHD is associated with worse outcomes in sarcoidosis.
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| http://dx.doi.org/10.1016/j.cpcardiol.2023.101866 | DOI Listing |
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