Statistical regularities and predictions can influence the earliest stages of visual processing. Studies examining their effects on detection, however, have yielded inconsistent results. In continuous flash suppression (CFS), where a static image projected to one eye is suppressed by a dynamic image presented to the other, the predictability of the suppressed signal may facilitate or delay detection. To identify the factors that differentiate these outcomes and dissociate the effects of expectation from those of behavioral relevance, we conducted three CFS experiments that addressed confounds related to the use of reaction time measures and complex images. In experiment 1, orientation recognition performance and visibility rates increased when a suppressed line segment completed a partial shape surrounding the CFS patch, demonstrating that valid configuration cues facilitate detection. In Experiment 2, however, predictive cues marginally affected visibility and did not modulate localization performance, challenging existing findings. In experiment 3, a relevance manipulation was introduced; participants pressed a key upon detecting lines of a particular orientation, ignoring the other possible orientation. Visibility and localization were enhanced for relevant orientations. Predictive cues modulated visibility, orientation recognition sensitivity, and response latencies, but not localization-an objective measure sensitive to partial breakthrough. Thus, while a consistent surround can strongly enhance detection during passive observation, predictive cueing primarily affects post-detection factors such as response readiness and recognition confidence. Relevance and predictability did not interact, suggesting that the contributions of these two processes to detection are mostly orthogonal.
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http://dx.doi.org/10.1016/j.cognition.2023.105506 | DOI Listing |
J Med Internet Res
December 2024
Guangzhou Cadre and Talent Health Management Center, Guangzhou, China.
Background: Large language models have shown remarkable efficacy in various medical research and clinical applications. However, their skills in medical image recognition and subsequent report generation or question answering (QA) remain limited.
Objective: We aim to finetune a multimodal, transformer-based model for generating medical reports from slit lamp images and develop a QA system using Llama2.
Comput Biol Chem
December 2024
Faculty of Biochemistry and Molecular Medicine, University of Oulu, PO Box 5400, Oulu 90014, Finland; Biocenter Oulu, University of Oulu, PO Box 5400, Oulu 90014, Finland. Electronic address:
Single-stranded breaks (SSBs) are the most frequent DNA lesions threatening genomic integrity-understanding how DNA sensor proteins recognize certain SSB types is crucial for studies of the DNA repair pathways. During repair of damaged DNA the final SSB that is to be ligated contains a 5'-phosphorylated end. The present work employed molecular simulation (MD) of DNA with a phosphorylated break in solution to address multiple questions regarding the dynamics of the break site.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Clinical Hospital of the Ribeirão Preto Medical School of the University of São Paulo (HCFMRP-USP), Ribeirão Preto, São Paulo, Brazil.
Background: Spatial orientation involves egocentric and allocentric strategies that switch in the brain. Disturbances in switching may indicate Neurocognitive Disorders, which contribute to early detection of Alzheimer's Disease. The "Ego-Allo-Switching Task" (EAST) needs to be adapted for cross-cultural use in Brazil.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Massachusetts General Hospital, Boston, MA, USA.
Background: Orientation in time, space, and person is often impaired in Alzheimer's disease dementia. Subtle changes in orientation may occur in prodromal and preclinical disease stages. Here we aim to assess the cross-sectional association between individuals' orientation to their own world, as measured with a novel AI-based paradigm, and Alzheimer's disease biomarkers (amyloid and tau) in cognitively unimpaired older adults.
View Article and Find Full Text PDFBackground: Mild Cognitive Impairment (MCI) and Mild Behavioral Impairment (MBI) represent transitional states between normal aging and incipient dementia. We examined whether presence of cognitive complaint (CC), MCI, and MBI differentially predicted risk for all-cause dementia or Alzheimer's disease (AD) in a population-based sample.
Method: Participants included 598 older adults [55% female, with mean (SD) age = 78.
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