A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 994
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3134
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Silver-Containing Biomaterials for Biomedical Hard Tissue Implants. | LitMetric

Silver-Containing Biomaterials for Biomedical Hard Tissue Implants.

Adv Healthc Mater

State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, China.

Published: October 2023

AI Article Synopsis

  • Bacterial infections associated with biomaterials used in implants pose serious challenges, especially due to rising antibiotic resistance, prompting a search for alternative antibacterial solutions.
  • Silver is emerging as a promising antibacterial agent due to its effectiveness and lower likelihood of inducing bacterial resistance, despite its potential cytotoxic effects that can hinder tissue regeneration.
  • The paper reviews key areas regarding silver's application in biomaterials, including maintaining its antibacterial properties without developing resistance, combining it with biomaterials effectively, and exploring further research needed for its use in hard tissue implants.

Article Abstract

Bacterial infection caused by biomaterials is a very serious problem in the clinical treatment of implants. The emergence of antibiotic resistance has prompted other antibacterial agents to replace traditional antibiotics. Silver is rapidly developing as an antibacterial candidate material to inhibit bone infections due to its significant advantages such as high antibacterial timeliness, high antibacterial efficiency, and less susceptibility to bacterial resistance. However, silver has strong cytotoxicity, which can cause inflammatory reactions and oxidative stress, thereby destroying tissue regeneration, making the application of silver-containing biomaterials extremely challenging. In this paper, the application of silver in biomaterials is reviewed, focusing on the following three issues: 1) how to ensure the excellent antibacterial properties of silver, and not easy to cause bacterial resistance; 2) how to choose the appropriate method to combine silver with biomaterials; 3) how to make silver-containing biomaterials in hard tissue implants have further research. Following a brief introduction, the discussion focuses on the application of silver-containing biomaterials, with an emphasis on the effects of silver on the physicochemical properties, structural properties, and biological properties of biomaterials. Finally, the review concludes with the authors' perspectives on the challenges and future directions of silver in commercialization and in-depth research.

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202300932DOI Listing

Publication Analysis

Top Keywords

silver-containing biomaterials
16
hard tissue
8
tissue implants
8
high antibacterial
8
bacterial resistance
8
application silver-containing
8
silver biomaterials
8
biomaterials
7
silver
7
antibacterial
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!