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Current and Future Role of Circulating DNA in the Diagnosis and Management of Urothelial Carcinoma.
Am Soc Clin Oncol Educ Book
January 2025
Division of Oncology, Department of Medicine, University of Washington, Seattle, WA.
The growing sophistication of tumor molecular profiling has helped to slowly transition oncologic care toward a more personalized approach in different tumor types, including in bladder cancer. The National Comprehensive Cancer Network recommends that all patients with stage IVA and stage IVB urothelial carcinoma have molecular analysis that integrates at least testing to help facilitate the selection of future therapeutic options. Sequencing of tumor-derived tissue is the mainstay to obtain this genomic testing, but as in other cancers, there has been extensive research into the integration of liquid biopsies in longitudinal management.
View Article and Find Full Text PDFNationwide guideline implementation: a qualitative study of barriers and facilitators from the perspective of guideline organizations.
BMC Health Serv Res
January 2025
Amsterdam UMC, Department of Public and Occupational Health, Vrije Universiteit Amsterdam, Amsterdam Public Health research institute, Van der Boechorststraat 7, NL-1081 BT, Amsterdam, The Netherlands.
Background: Although the number of Dutch guidelines is growing, their uptake and impact in clinical practice lag behind. Dutch guideline organizations, including guideline developers, governmental agencies, health insurers and other national organizations, play a crucial role in developing, authorizing and/or supporting the use of guidelines. They influence end users' awareness, accessibility, understanding, acceptability and applicability of guidelines.
View Article and Find Full Text PDFBayesian Analysis of Exponential Random Graph Models Using Stochastic Gradient Markov Chain Monte Carlo.
Bayesian Anal
June 2024
Department of Statistics, Purdue University, West Lafayette, IN 47907, USA.
The exponential random graph model (ERGM) is a popular model for social networks, which is known to have an intractable likelihood function. Sampling from the posterior for such a model is a long-standing problem in statistical research. We analyze the performance of the stochastic gradient Langevin dynamics (SGLD) algorithm (also known as noisy Longevin Monte Carlo) in tackling this problem, where the stochastic gradient is calculated via running a short Markov chain (the so-called inner Markov chain in this paper) at each iteration.
View Article and Find Full Text PDFEvolving Immunotherapy Strategies in Gastrointestinal Neuroendocrine Neoplasms.
Curr Treat Options Oncol
January 2025
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Treatment for neuroendocrine neoplasms (NENs) is tailored to the tumor's site of origin, grade, and differentiation. NENs are categorized into two main types: well-differentiated neuroendocrine tumors (NETs), which tend to grow more slowly and are less aggressive, and poorly differentiated neuroendocrine carcinomas (NECs), which are highly aggressive and harder to treat. Treatment options for NETs range from somatostatin analogues and mTOR inhibitors to peptide receptor radionuclide therapy (PRRT) with Lutetium-177 dotatate.
View Article and Find Full Text PDFSlow-Release Pharmaceutical Implants in Ecotoxicology: Validating Functionality across Exposure Scenarios.
ACS Environ Au
January 2025
Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences, Umeå SE-907 36, Sweden.
Pharmaceutical contaminants have spread in natural environments across the globe, endangering biodiversity, ecosystem functioning, and public health. Research on the environmental impacts of pharmaceuticals is growing rapidly, although a majority of studies are still conducted under controlled laboratory conditions. As such, there is an urgent need to understand the impacts of pharmaceutical exposures on wildlife in complex, real-world scenarios.
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