Quinazolin-4-one derivatives possessing an isotopic atropisomerism (isotopic N-C axial chirality) based on -CH/CH discrimination were prepared. The diastereomeric quinazolin-4-ones bearing an asymmetric carbon as well as an isotopic atropisomerism were clearly discriminated by H and C NMR spectra and revealed to possess high rotational stability and stereochemical purity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.joc.3c01004 | DOI Listing |
Publication Analysis
Top Keywords
isotopic atropisomerism
8
synthesis isotopic
4
isotopic atropisomers
4
atropisomers based
4
based c/c
4
c/c discrimination
4
discrimination quinazolin-4-one
4
quinazolin-4-one derivatives
4
derivatives possessing
4
possessing isotopic
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!