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Complex Extract of and Improves Menopause Symptoms via Regulation of Estrogen Receptor Beta in an Ovariectomized Rat Model. | LitMetric

AI Article Synopsis

  • Menopause leads to hormone deficiencies causing various symptoms like facial flushing, vaginal dryness, and increased risks of health issues, and is often treated with hormone-replacement therapy, which can have serious side effects.
  • A study used an ovariectomized rat model to test a complex extract on menopause symptoms, finding it better restored vaginal health and improved blood-lipid levels compared to single extracts.
  • The complex extract worked by enhancing ERβ expression without affecting ERα in the uterus, suggesting it could be a natural option for relieving menopause symptoms without the risks associated with traditional hormone therapies.

Article Abstract

Menopause is a hormone-deficiency state that causes facial flushing, vaginal dryness, depression, anxiety, insomnia, obesity, osteoporosis, and cardiovascular disease as ovarian function decreases. Hormone-replacement therapy is mainly used to treat menopause; however, its long-term use is accompanied by side effects such as breast cancer and endometriosis. To identify the effect of a complex extract of () and () on improving menopause without side effects, an ovariectomized rat model was established to analyze several menopause symptoms. Compared to single extracts, the complex extract restored vaginal epithelial cell thickness and decreased serotonin concentration by increasing the estrogen receptors ERα (ESR1) and ERβ (ESR2), depending on the ratio. Although the complex extract exerted a lower weight-loss effect than the single extracts, improved blood-lipid metabolism was observed after increasing high-density lipoprotein cholesterol levels and decreasing low-density lipoprotein cholesterol and triglyceride levels, and ovariectomy-induced osteoporosis was alleviated by suppressing osteoclast production. Thus, by increasing only ERβ expression without regulating ERα expression in the uterus, the complex extract of PS and NS may be a natural treatment for improving menopause symptoms without side effects, such as endometriosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10255448PMC
http://dx.doi.org/10.3390/nu15112443DOI Listing

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