AI Article Synopsis
- Zinc is an essential trace element that plays a role in immune function, and its deficiency is linked to immune abnormalities, especially in the context of colorectal cancer.
- Research involving mice treated with chemicals to induce colorectal cancer showed that higher dietary zinc reduced tumor number and size, with significant differences observed between low-zinc and high-zinc groups.
- The study indicates that zinc’s tumor-suppressive effects depend on T cells and enhance the production of granzyme B, a molecule crucial for immune response, suggesting that zinc may help boost tumor immunity.
Article Abstract
Zinc is one of the essential trace elements and is involved in various functions in the body. Zinc deficiency is known to cause immune abnormalities, but the mechanism is not fully understood. Therefore, we focused our research on tumor immunity to elucidate the effect of zinc on colorectal cancer and its mechanisms. Mice were treated with azoxymethane (AOM) and dextran sodium sulfate (DSS) to develop colorectal cancer, and the relationship between zinc content in the diet and the number and area of tumors in the colon was observed. The number of tumors in the colon was significantly higher in the no-zinc-added group than in the normal zinc intake group, and about half as many in the high-zinc-intake group as in the normal-zinc-intake group. In T-cell-deficient mice, the number of tumors in the high-zinc-intake group was similar to that in the normal-zinc-intake group, suggesting that the inhibitory effect of zinc was dependent on T cells. Furthermore, we found that the amount of granzyme B transcript released by cytotoxic T cells upon antigen stimulation was significantly increased by the addition of zinc. We also showed that granzyme B transcriptional activation by zinc addition was dependent on calcineurin activity. In this study, we have shown that zinc exerts its tumor-suppressive effect by acting on cytotoxic T cells, the center of cellular immunity, and increases the transcription of granzyme B, one of the key molecules in tumor immunity.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253514 | PMC |
| http://dx.doi.org/10.3390/ijms24119457 | DOI Listing |
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