AI Article Synopsis
- - Voltage-gated calcium channels (VGCCs) are important targets for developing treatments for pain conditions, as they play a key role in pain processing.
- - The review discusses both natural and synthetic blockers of VGCCs, emphasizing the latest findings on drug development that targets specific VGCC subtypes or uses mixed strategies for improved pain relief.
- - It highlights the pre-clinical and clinical evidence supporting these new VGCC-targeted analgesic drugs, aiming for better pain management options.
Article Abstract
Voltage-gated calcium channels (VGCCs) are targeted to treat pain conditions. Since the discovery of their relation to pain processing control, they are investigated to find new strategies for better pain control. This review provides an overview of naturally based and synthetic VGCC blockers, highlighting new evidence on the development of drugs focusing on the VGCC subtypes as well as mixed targets with pre-clinical and clinical analgesic effects.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252546 | PMC |
| http://dx.doi.org/10.3390/ijms24119223 | DOI Listing |
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