Allograft vasculopathy (AV) leads to chronic rejection of organ transplants, but its causes are obscure. New research from the Jane-Wit laboratory showed that Sonic Hedgehog (SHH) signalling from damaged graft endothelium drives vasculopathy by promoting proinflammatory cytokine production and NLRP3-inflammasome activation in alloreactive CD4PTCH1PD-1T memory cells, offering new diagnostic and therapeutic strategies.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569892 | PMC |
| http://dx.doi.org/10.1016/j.tips.2023.05.005 | DOI Listing |
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