AI Article Synopsis
- - Iron-sulfur clusters ([FeS]) have been crucial for life on Earth since prebiotic times, contributing to essential biological processes such as respiration and immune response.
- - The text focuses on three specific [FeS] proteins involved in the innate immune response and their influence on oncogene activity and metabolism related to cancer.
- - Future research on [FeS] clusters is vital for uncovering their roles in cancer development, which could lead to new targets for anticancer drugs.
Article Abstract
Inorganic complexes of iron and sulfur, that is, iron-sulfur [FeS] clusters, have played a fundamental role in life on Earth since the prebiotic period. These clusters were involved in elementary reactions leading to the emergence of life and, since then, gained function in processes, such as respiration, replication, transcription, and the immune response. We discuss how three [FeS] proteins involved in the innate immune response play a role in oncogene expression/function and oncometabolism. Our analysis highlights the importance of future research into understanding the [FeS] clusters' roles in cancer progression and proliferation. The outcomes of these studies will help identify new targets and develop new anticancer therapeutics.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cbpa.2023.102338 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exposure to Cadmium and Other Trace Elements Among Individuals with Mild Cognitive Impairment.
Toxics
December 2024
Environmental, Genetics, and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Background: A limited number of studies have investigated the role of environmental chemicals in the etiology of mild cognitive impairment (MCI). We performed a cross-sectional study of the association between exposure to selected trace elements and the biomarkers of cognitive decline.
Methods: During 2019-2021, we recruited 128 newly diagnosed patients with MCI from two Neurology Clinics in Northern Italy, i.
Removal of the Active Pharmaceutical Substance Entecavir from Water via the Fenton Reaction or Action by the Cyanobacterium .
Toxics
December 2024
Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
Entecavir (ETV) is an antiviral used to treat chronic infection caused by the hepatitis B virus, which affects approximately 250 million people worldwide. In order to mitigate the impacts of ETV on the environment, including potential harm to human health, this study evaluated the use of the Fenton-like reaction, which uses iron complexed with ethylenediaminetetraacetic acid (EDTA) at neutral pH, and the microbiological action of in removing ETV from the aqueous medium. Aqueous concentrations of 100 mg/L were subjected to Fenton-like degradation.
View Article and Find Full Text PDFThe Nutrient-Skin Connection: Diagnosing Eating Disorders Through Dermatologic Signs.
Nutrients
December 2024
Department of Biomedical Sciences, School of Health and Care Sciences, University of West Attica, GR-12243 Athens, Greece.
The interplay between nutrition and skin health provides a crucial lens for understanding, diagnosing, and managing eating disorders (EDs) such as anorexia nervosa (AN), bulimia nervosa (BN), and binge-eating disorder (BED). This review explores the dermatological manifestations resulting from the nutritional deficiencies commonly associated with EDs, including conditions like hair loss, xerosis, and brittle nails. These changes in the skin and its appendages often reflect deeper systemic dysfunctions, such as deficiencies in essential micronutrients (zinc, iron, and vitamins A and C), hormonal imbalances, and electrolyte disturbances.
View Article and Find Full Text PDFThe Daunomycin: Biosynthesis, Actions, and the Search for New Solutions to Enhance Production.
Microorganisms
December 2024
VUAB Pharma A.S, Nemanicka 2722, 370 01 České Budějovice, Czech Republic.
Daunorubicin (DNR) is an anthracycline antibiotic originating from soil-dwelling actinobacteria extensively used to treat malignant tumors. Over the decades, extensive attempts were made to enhance the production of anthracyclines by introducing genetic modifications and mutations in combination with media optimization, but the target production levels remain comparatively low. Developing an appropriate culture medium to maximize the yield of DNR and preventing autotoxicity for the producing organism remains a challenge.
View Article and Find Full Text PDFStructural Characterization of Encapsulin in Complex with Dye-Decolorizing Peroxide.
Microorganisms
November 2024
Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA.
(Mtb) is the causative agent of tuberculosis, the world's deadliest infectious disease. Mtb uses a variety of mechanisms to evade the human host's defenses and survive intracellularly. Mtb's oxidative stress response enables Mtb to survive within activated macrophages, an environment with reactive oxygen species and low pH.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!